Functional disparity between human PAWP and PLCζ in the generation of Ca2+oscillations for oocyte activation
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چکیده
منابع مشابه
Functional disparity between human PAWP and PLCζ in the generation of Ca2+ oscillations for oocyte activation.
Mammalian oocyte activation is mediated by cytosolic calcium (Ca(2+)) oscillations initiated upon delivery of a putative 'sperm factor' by the fertilizing sperm. Previous studies suggest the identity of this sperm factor as the testis-specific phospholipase C-zeta (PLCζ). Recently, a post-acrosomal sheath WW domain-binding protein (PAWP) has been proposed as an alternative sperm factor candidat...
متن کاملHuman PLCζ exhibits superior fertilization potency over mouse PLCζ in triggering the Ca(2+) oscillations required for mammalian oocyte activation.
A sperm-specific phospholipase C-zeta (PLCζ) is believed to play an essential role in oocyte activation during mammalian fertilization. Sperm PLCζ has been shown to trigger a prolonged series of repetitive Ca(2+) transients or oscillations in oocytes that precede activation. This remarkable intracellular Ca(2+) signalling phenomenon is a distinctive characteristic observed during in vitro ferti...
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Evaluation of PLCζ and PAWP Expression in Globozoospermic Individuals
OBJECTIVE Globozoospermia is a rare type of teratozoospermia with incidence of 0.1% among infertile individuals. Phospholipase C zeta (PLCζ) and postacrosomal sheath WW domain binding protein (PAWP) are the main candidates in sperm taking responsibility for oocyte activation during fertilization. Therefore, we aimed to evaluate the expression of these two genes at RNA and protein levels in glob...
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ژورنال
عنوان ژورنال: Molecular Human Reproduction
سال: 2015
ISSN: 1360-9947,1460-2407
DOI: 10.1093/molehr/gav034